We treated 350 patients With Condyloma acuminatum by CO2Laser. The result were 327 cases cued for one time, cured rate was 93.4%, 23 cases cured for wice times. Total cured rate was 100%. Cured time were7-12 days. No apparent side effects were observed in all patients. Treating features by CO2laser are easy to perform,lower-price, less side effects higher cured rate.