Based on USB specification,a new design method for CCD high-speed data acquisition system is proposed.Through the analysis of USB-based DMA,a structure without external buffer is adopted to obtain high-speed data transfer.It has some advantages such as high precision.simple structure and so on.The design of hardware,firmware,device driver,and application program are described in detail.The experimental results show that the scheme can realize high-speed and high-resolution CCD signal quantization and data transfer.