For multi-input multi-output (MIMO) indoor visible light communicati on (VLC),this paper analyzes the impact of antenna layout on the system performance by changing the spatial distr ibution of light-emitting diodes (LEDs) and optical receivers.In this paper,we use a channel model,which is bas ed on Lambertian radiation,to estimate the channel state matrix.The MIMO technique used in the system consists of three well-known aspects,repetition coding (RC),spatial multiplexing (SMP) and spatial modulation (SM).Two types of systems are analyzed in this paper.The first case is a 4×6system,which uses 4LEDs at the transmitter side arranged in square layout and 6detectors at receivers arranged in hexagonal,rectangular an d triangular layouts.As shown in the simulation results,the triangular layout gives the best bit error rate 〖W TB X〗(BER) performance for RC at the center of the room.The BER curves of hexagonal and triangular layouts are almost coincident for SMP and SM,which are both better than the BER curve of rectangle layout.If the receiver is not at the cen ter of the room,the hexagonal layout is the best choice.The second case is an 8×8system with LEDs and photo detectors using octagonal,square layouts respectively.The simulation results show that the system using square l ayout in the transmitter has better BER performance than that using the octagonal layout.