OptiGrating,a type of software for fib er Bragg grating (FBG) analysis,was used for systematic theoretical simulation o f temperature and strain sensingof tilted fiber Bragg grating (TFBG).The results show that the change of both temperature and strain can lead to the drift of harmonic peak of core mode and cladding mode of TFBG,while temperature and strain have different impacts on core mode an d cladding mode.In accordance with such a feature of TFBG,a sensing system based on single TFBG for measuring temperature and strain simultaneously is proposed and then ve rified by experiments. In the experiment,the photo detector is able to transform the wavelength drift o f the TFBG to voltage variations.Thus it can be concluded that the core mode vol tage and clad mode voltage (peak-peak value) both show linear variation with the curve slopes of 0.06339mV/℃ and 0.00189mV/℃,respectively,as only the temperature changes. The core mode voltage and clad mode voltage (peak-peak value) also show linear variation with the curve slopes of 0.00959mV/με and 0.00196mV/με, respectively,as only the strain changes.Our findings can be used to guide the se nsing application of TFBG.