In order to improve the measurement efficiency and measurement accurac y,a laser total station measurement system based on vision guidance is proposed.The measurement system consists of a non-orthogonal laser total station and a zoom camera.This paper firstly introduces the structure design of the measurement system,followed by the analysis of measurem ent method of non-orthogonal laser total station and precise guiding strategy,finally stabil ity and accuracy of the measurement system is verified through real experiment.The experiment shows tha t the method is simple and effective,improves the measurement efficiency,and has a measurement accuracy of millimeters,which demonstrates proposed measurement system has high practical v alue in large space measurement of tunnels,buildings and so on.