To discuss the effect of narrow-band ultraviolet B (NV-UVB) combined with halometasone on the skin inflammation and melanocyte (MC) functio n in patients with vitiligo vulgaris.100patients with vitiligo vulgar is were selected from January 2017to December 2018in our hospital,according t o the random number table,they were divided into A group and B group,50cases in each group.The B group was treated with 0.05% halometasone,the A group was treated with NV-UVB on this basis,the skin inflammation [interleukin (IL)-2, IL -17,IL-22],MC function [MC,alpha-melanocyte stimulating hormone (alpha-MS H)], therapeutic efficacy and adverse reactions were compared between the two groups .Results:The IL-2,IL-17and IL-22in combination group and B group after t rea tment were significantly lower than those in before treatment,the IL-2,IL-17a nd IL-22in combination group after treatment were significantly lower than tho s e in B group,the difference was statistically significant (P<0.05).The MC an d alpha-MSH in combination group and B group after treatment were significantly higher than those in before treatment,the MC and alpha-MSH in combination grou p after treatment were significantly higher than those in B group,the difference was statistically significant (P<0.05).The effective ra te in combination gr oup was 94.00%,it was significantly higher than the 80.00% in B group,the diffe rence was statistically significant (P<0.05).The adverse reaction rate in B group and A group were 10.00% and 14.00%,there was no significant difference bet ween the two groups (P>0.05).Conclusions:NV-UVB combine d with halometasone c an effectively improve the skin inflammation and MC function in patients with vi tiligo vulgaris,which is conducive to improving the therapeutic effect of patie nts,and it has the good safety,it′s worth for further clinical promotion.