The cause of cardiovascular disease is closely related to the mechanic al properties of blood vessels.In order to accurately measure the deformation r esponse of blood vessel cross-sections under different pressure conditions,thi s paper combines optical coherence tomography (OCT) with an injection loading dev ice to acquire the cross-sectional images of blood vessels under different pres s ure conditions;The influence of light refraction on imaging is analyzed,and th e correction method of OCT image of blood vessel cross-section is proposed;dig ital image correlation (DIC) method is used to process the corrected images to measure the deformation of the blood vessel cross-section,a set of blood ve s sel cross-section deformation test system and method is developed finally.The v erification experiment of the correction of OCT image verifies the necessity and effectiveness of the refraction rectification method.The vascular mimic experi ment verifies the reliability of the developed system and method.The developed system and method are also applied to the deformation measurement of the pig blo od vessel sample,the full field displacement and strain of the pig blood vessel wall section under different pressure conditions are obtained.