In order to solve the high-precision interactive control problem of la ser Raman spectrometer,this paper proposes a reliable and stable multi-channel communica tion interactive system. The system integrates the required functions into the visual interface through h uman-computer interaction technology,so as to enhance the convenience of Raman spectrometer op eration. In the communication technology of the multi-channel Ra man spectrometer,stable and reliable communication technology and phase-locked loo p technology are adopted.Aiming at the clock drift problem caused by the aging of the crystal oscillator and electromagnetic interference in the actual communication process,this paper uses the clock Kalman filter algorithm to estimate the error,and finally performs error compensation in the program design,which greatly improves the accuracy of infor mation data transmission.Experiments show that this communication interactive system h as stable and reliable data transmission and convenient control functions.