Deformation image registration (DIR) is a key process of contour derivation and dose accumulation in adaptive radiotherapy (ART).This study compares the changes of contour derivation and dose accumulation in the process of adaptive radiotherapy with th ree different deformation registration algorithms.The radiotherapy imaging data images of pat ients with head and neck cancer were selected for this study.After rigid registration,B-splin e elastic registration and LCC-Demons registration algorithms were used.The B-spline elastic algorit hm studied two optimization indexes:normalization Cross-correlation,normalized cross-correl ation combined with bending energy penalty (BEP) regularization.Dose evaluation uses dose parameters D₉₅,Dmin, Dmean,Dmax and unifo rmity index (HI) to evaluate the difference between cumulative dose and initial dose.Geometric evaluation uses Dice correlation coefficient (DCS) and H ausdorff distance (HD) to evaluate the degree of overlap between volumes.After experiments,the Dice coefficients of the planning target volume (PTV) target area,left parotid gland and right parotid gland obtained by geometri c evaluation are respectively 0.82±0.07,0.83±0.07,0.86±0.08in the two optimization algorith ms of B-spline elastic registration and the LCC-Demons algorithm.Among them,the Dice coeffic ient obtained under the LCC-Demons algorithm reached the maximum value of 0.91, and the obtai ned Hausdorff distances were all between 1and 3mm.The DSC overlap result and the indicated deviation distance were both within the clinically acceptable range.For dose evaluation,the corr esponding HI values are:1.089,1.082,1.081,LCC-Demons also reached the minimum value of 1.081.I n this experiment, LCC-demons achieved good results in contour derivation and dose mapping,and it is also clinical it provides a certain reference for the evaluation of registration quality in th e environment.